Solvent usage is a core requirement in most synthetic chemistry disciplines, so introducing them into a glovebox environment is unavoidable, especially in organometallic chemistry. However, solvent fumes will damage the reactor and other parts of the glovebox over time, so a solvent filter is needed to protect the rest of the system. Even with a filter, it is best practice to limit the time the system is exposed to fumes while working.

Large amounts of liquids, such as solvents, are best transferred into the box using a round-bottom flask equipped with a Young-type PTFE valve (Figure 1). Do not use regular flasks with standard glass stoppers, as they may not withstand the reduced pressure inside an evacuated antechamber, even if they are properly clamped.With the right type of flask (1 liter) and design, it should fit into modern small antechambers. Note that the antechambers used in older glovebox models are usually significantly smaller.